2-Hydroxypropyl-β-cyclodextrin Promotes Transcription Factor EB-mediated Activation of Autophagy
نویسندگان
چکیده
منابع مشابه
2-Hydroxypropyl-β-Cyclodextrin Acts as a Novel Anticancer Agent
2-Hydroxypropyl-β-cyclodextrin (HP-β-CyD) is a cyclic oligosaccharide that is widely used as an enabling excipient in pharmaceutical formulations, but also as a cholesterol modifier. HP-β-CyD has recently been approved for the treatment of Niemann-Pick Type C disease, a lysosomal lipid storage disorder, and is used in clinical practice. Since cholesterol accumulation and/or dysregulated cholest...
متن کاملInduction of Dendritic Cell Maturation and Activation by a Potential Adjuvant, 2-Hydroxypropyl-β-Cyclodextrin
2-Hydroxypropyl-β-cyclodextrin (HP-β-CD) is a chemically modified cyclic oligosaccharide produced from starch that is commonly used as an excipient. Although HP-β-CD has been suggested as a potential adjuvant for vaccines, its immunological properties and mechanism of action have yet to be characterized. In the present study, we investigated the maturation and activation of human dendritic cell...
متن کاملAutophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice
BACKGROUND Mutant huntingtin (mHTT) is encoded by the Huntington's disease (HD) gene and its accumulation in the brain contributes to HD pathogenesis. Reducing mHTT levels through activation of the autophagosome-lysosomal pathway may have therapeutic benefit. Transcription factor EB (TFEB) regulates lysosome biogenesis and autophagy. OBJECTIVE To examine if increasing TFEB protein levels in H...
متن کاملEncapsulation Mechanism of Oxyresveratrol by β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin and Computational Analysis.
In this study, the encapsulation mechanism of oxyresveratrol and β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) was studied. As this research shows, oxyresveratrol and two cyclodextrins (CDs) were able to form inclusion complexes in a 1:1 stoichiometry. However, the interaction with HP-β-CD was more efficient, showing up as higher encapsulation constant (KF) (35,864.72 ± 3415....
متن کاملPhotoinduced guest transformation promotes translocation of guest from hydroxypropyl-β-cyclodextrin to cucurbit[7]uril.
We report that three-component systems comprising styryl dyes (1 or 2) and two hosts (hydroxypropyl-β-cyclodextrin (HP-β-CD) and cucurbit[7]uril (CB[7])) undergo photoinduced transformation and translocation of the styryl guest from the cavity of HP-β-CD to CB[7]. We find that the protonation of guest trans-1 or the addition of Ba(2+) as competitor for CB[7] triggers dissociation of the contain...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2014
ISSN: 0021-9258
DOI: 10.1074/jbc.m113.506246